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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 290-303 doi: 10.1007/s11684-022-0956-8

Abstract: was identified as a target of benzydamine by molecular docking, pull-down assay and in vitro kinase

Keywords： benzydamine     cyclin-dependent kinase 2     patient-derived xenograft     esophageal squamous cell carcinoma    

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The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 384-389 doi: 10.1007/s11684-009-0070-1

Abstract: In the present report, cyclin-dependent kinase1 (CDK1) siRNA was transfected into cells to silence theCDK1 gene expression and study its role in the cell cycle and cell apoptosis.The siRNA targeting CDK1 gene was chemically synthesized and transfected into Hela cells by lipofectamineThe expression levels of CDK1 gene and protein were examined by real-time quantitative polymerase chainCDK1 gene was successfully silenced by its siRNA, and the CDK1 protein expression level was decreased

Keywords： cyclin-dependent kinase1     siRNA interference     cell cycle     apoptosis    

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Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene

Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 287-291 doi: 10.1007/s11684-009-0050-5

Abstract: In order to explore the role of cyclin-dependent kinase 4 (cdk4) in neurodegenerative diseases, lentiviral-deliveredAfter synthesis and annealing, double strand oligonucleotides were cloned into a linearized pSIH1-H1-sequencing that three pairs of cdk4-shRNAs and a negative shRNA were correctly inserted into the pSIH1-H1-copGFP vector.The optimized pSIH1-cdk4-siRNA2 and pSIH-negative-siRNA were co-transfected into 293T cells with the

Keywords： cyclin-dependent kinase 4     RNA interference     plasmid     lentiviral vector    

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Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 481-489 doi: 10.1007/s11684-016-0494-3

Abstract:

The tumor suppressor gene liver kinase B1 (LKB1), also called STK11, encodes a serine/threonine kinaseLKB1 plays crucial roles in cell differentiation, proliferation, and polarity.In this study, LKB1 conditional knockout mice (LKB1Pax2 CKO mice) were generated usingLKB1Pax2 CKO mice died perinatally.LKB1 deficiency in LKB1Pax2 CKO mice thus disrupted hair cell planar polarity during

Keywords： LKB1     stereociliary bundles     kinocilium     planar cell polarity     hearing     mice    

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PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 399-403 doi: 10.1007/s11684-014-0380-9

Abstract:

We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinase1 (PAK1), a member of a serine/threonine protein kinase family.Despite the large body of evidence from studies in noncardiac tissue indicating that PAK1 activity iskey in the regulation of a number of cellular functions, the role of PAK1 in the heart has only beenWe discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its

Keywords： p21-activated kinase 1 (PAK1)     heart    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 52-60 doi: 10.1007/s11684-016-0433-3

Abstract: In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressedKaplan-Meier and Cox regression data indicated that PPM1D overexpression was an independent predictorOverexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdownof PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target

Keywords： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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breast cancer cells from accumulating replication stress by ensuring productive splicing of checkpoint kinasecancer cells from accumulating replication stress by ensuring productive splicing of checkpoint kinase 1

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 186-195 doi: 10.1007/s11705-015-1540-4

Abstract: These exons include a critical exon within the checkpoint kinase 1 (CHK1) gene that plays a crucial functionBreast cancer cells depleted for Tra2 proteins have reduced CHK1 protein levels and accumulate DNA damage

Keywords： RNA splicing     gene expression     breast cancer     DNA damage     CHK1    

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Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 705-712 doi: 10.1007/s11684-019-0703-y

Abstract: the interactions between Notch and Wnt signaling on the basis of the bidirectional regulation of Notch1We found that the downregulation of Notch1 in Lgr5 cells from embryonic day (E) 14.5 to E18.5 can drivecells to re-enter the cell cycle and differentiate into extra HCs, whereas the upregulation of Notch1No effect was observed on the upregulation or downregulation of Notch1 in Lgr5 cells from E10.5 to E14.5We concluded that the roles of Notch1 in Wnt-responsive Lgr5 cells are unidirectional and stage dependent

Keywords： inner ear     cochlear     Wnt     Notch     Lgr5     auditory system    

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Machine learning based altitude-dependent empirical LoS probability model for air-to-ground communications Research Article

Minghui PANG, Qiuming ZHU, Zhipeng LIN, Fei BAI, Yue TIAN, Zhuo LI, Xiaomin CHEN

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 9,   Pages 1378-1389 doi: 10.1631/FITEE.2200041

Abstract: This paper presents an altitude-dependent empirical LoS probability model for A2G scenarios.

Keywords： Line-of-sight probability model     Air-to-ground channel     Machine learning     Ray tracing    

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Stabilization of switched linear systems under asynchronous switching subject to admissible edge-dependent Research Article

Linlin HOU, Xuan MA, Haibin SUN,houtingting8706@126.com,maxuan24@163.com,fengyun198212@163.com

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 5,   Pages 810-822 doi: 10.1631/FITEE.2000698

Abstract: The problem of stabilizing switched linear systems under is addressed. The method is applied to design a switching signal that comprises slow and fast . Under this switching signal, the restriction that the maximum delay of is known in advance is removed. The constructed Lyapunov function is associated with both the system mode and controller mode. The stabilization criteria and the corresponding algorithm are presented to obtain the controller gains and to design the switching signal. Finally, two examples are given to demonstrate the effectiveness of the proposed results.

Keywords： Asynchronous switching     Admissible edge-dependent average dwell time     Multi-Lyapunov function    

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Discovery of small molecule degraders for modulating cell cycle

Frontiers of Medicine   Pages 823-854 doi: 10.1007/s11684-023-1027-5

Abstract: Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate theIn this article, we aim to summarize the latest developments of CDKs and cyclin protein degraders.Overall, this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein

Keywords： PROTAC     molecular glue     degrader     cell cycle     CDK     cyclin    

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The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract:

Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.

Keywords： protein kinase C ?     signal transduction     neurogenic disease    

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Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 383-388 doi: 10.1007/s11684-016-0488-1

Abstract:

The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming the

Keywords： EGFR     tyrosine kinase inhibitor     AZD9291     EAI045    

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Data-driven approach to solve vertical drain under time-dependent loading

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 3,   Pages 696-711 doi: 10.1007/s11709-021-0727-7

Abstract: , the vertical drain consolidation problem is solved by numerous analytical solutions, such as time-dependentDNN–GA prediction models with three different radial drainage patterns in the smear zone under time-dependent

Keywords： vertical drain     artificial neural network     time-dependent loading     deep learning network     genetic algorithm    

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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: The aim of this study is to investigate the effect of tyrosine kinase Src on Tyrosine 307(Y307) phosphorylation

Keywords： hyperphosphorylation     PP2A activity     cellular regulation     siRNA     siRNA transfection    

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Title Author Date Type Operation

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Journal Article

The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Journal Article

Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene

Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,

Journal Article

Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Journal Article

PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Journal Article

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Journal Article

breast cancer cells from accumulating replication stress by ensuring productive splicing of checkpoint kinasecancer cells from accumulating replication stress by ensuring productive splicing of checkpoint kinase 1

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Journal Article

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Journal Article

Machine learning based altitude-dependent empirical LoS probability model for air-to-ground communications

Minghui PANG, Qiuming ZHU, Zhipeng LIN, Fei BAI, Yue TIAN, Zhuo LI, Xiaomin CHEN

Journal Article

Stabilization of switched linear systems under asynchronous switching subject to admissible edge-dependent

Linlin HOU, Xuan MA, Haibin SUN,houtingting8706@126.com,maxuan24@163.com,fengyun198212@163.com

Journal Article

Discovery of small molecule degraders for modulating cell cycle

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Journal Article

Data-driven approach to solve vertical drain under time-dependent loading

Journal Article

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Journal Article